Nahata M C
Department of Pharmacy and Pediatrics, Ohio State University and Children's Hospital, Columbus, Ohio 43210-1291, USA.
Pediatrics. 1999 Sep;104(3 Pt 2):607-9.
Many drugs frequently used in infants and young children are not available in suitable dosage forms. Liquid dosage forms must be prepared extemporaneously, while using appropriate excipients. However, it is critical to determine the stability of various drugs at clinically important concentrations and practical storage conditions. It is of concern that few funding agencies are willing to support research on the development of stable liquid dosage forms for pediatric patients. The need for such data will continue, because it is unlikely that all drugs approved for adults will also be labeled simultaneously for potential use in infants and children. Presentations and publications on stable drug formulations will offer the opportunities for pediatric patients to receive the desired drugs and doses most effectively and safely.
许多常用于婴幼儿的药物没有合适的剂型。必须临时配制液体制剂，并使用适当的辅料。然而，确定各种药物在临床重要浓度和实际储存条件下的稳定性至关重要。令人担忧的是，很少有资助机构愿意支持针对儿科患者稳定液体制剂开发的研究。对这类数据的需求将持续存在，因为不太可能所有已批准用于成人的药物会同时标注可用于婴幼儿。关于稳定药物制剂的报告和出版物将为儿科患者提供机会，使其最有效、最安全地获得所需药物和剂量。
