Wall M S, Deng X H, Torzilli P A, Doty S B, O'Brien S J, Warren R F
Sports Orthopedic and Rehabilitation Medicine Associates (SOAR), Menlo Park, CA 94025, USA.
J Shoulder Elbow Surg. 1999 Jul-Aug;8(4):339-44. doi: 10.1016/s1058-2746(99)90157-x.
Shoulder capsular shrinkage has recently been proposed as a therapeutic modality in a select group of patients with instability. Basic science research studying the mechanism of collagen shrinkage and the effect of shrinkage on the tissue's mechanical properties is essential to define the ideal process by which to achieve optimal tissue shrinkage. Tissue shrinkage is a function of both time and temperature. This relationship was studied, and a model was derived to describe the relationship mathematically. Tissue shrinkage rate was extremely sensitive to temperature changes. The purpose of this study, was to shrink collagenous tissue thermally and then to measure the mechanical property changes as a function of tissue shrinkage. Uniaxial tensile testing of normal and heat-shrunken bovine tendon was carried out, and a model was developed to express the relationship between shrinkage and mechanical properties. We found that the mechanical properties decreased with increasing shrinkage, and that the maximal allowable shrinkage before significant material property changes occurred was between 15% to 20%. Ultrastructural analysis with transmission electron microscopy showed denaturation of the collagen fibrillar structure and provided direct support for the observed material changes.
最近，有人提出关节囊收缩可作为特定不稳定患者群体的一种治疗方式。研究胶原蛋白收缩机制以及收缩对组织力学性能影响的基础科学研究，对于确定实现最佳组织收缩的理想过程至关重要。组织收缩是时间和温度的函数。对这种关系进行了研究，并推导了一个模型来数学描述这种关系。组织收缩率对温度变化极为敏感。本研究的目的是对胶原组织进行热收缩，然后测量作为组织收缩函数的力学性能变化。对正常和热收缩的牛肌腱进行了单轴拉伸试验，并建立了一个模型来表达收缩与力学性能之间的关系。我们发现，力学性能随着收缩增加而降低，并且在材料性能发生显著变化之前的最大允许收缩率在15%至20%之间。透射电子显微镜的超微结构分析显示胶原纤维结构变性，并为观察到的材料变化提供了直接支持。
