Zheng T, Holford T R, Mayne S T, Ward B, Carter D, Owens P H, Dubrow R, Zahm S H, Boyle P, Archibeque S, Tessari J
Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA.
Am J Epidemiol. 1999 Sep 1;150(5):453-8. doi: 10.1093/oxfordjournals.aje.a010033.
A case-control study was conducted in Connecticut from 1994 to 1997 to investigate the relation between dichlorodiphenyldichloroethane (DDE) and dichlorodiphenyltrichloroethane (DDT) exposure and breast cancer risk. Cases and controls were women aged 40-79 years, who had breast-related surgery at the Yale-New Haven Hospital and from whose surgical specimen the authors could obtain at least 0.4 g of breast adipose tissue for chemical analyses. A total of 304 incident breast cancer cases (including 62 in situ carcinomas) and 186 benign breast disease controls were recruited into the study. Tissue levels of DDE and DDT were measured using gas chromatography. Statistical significance for comparisons of mean levels of DDE and DDT was calculated using analysis of variance and rank sum tests. A logistic regression model was used to estimate the association and to control confounding. The age-adjusted geometric mean tissue level of DDE for cases (736.5 ppb) was similar to that for the controls (784.1 ppb). DDT levels were also similar for cases (51.8 ppb) and controls (55.6 ppb). The adjusted odds ratio is 0.9 (95% confidence interval: 0.5, 1.5) for DDE and 0.8 (95% confidence interval: 0.5, 1.5) for DDT when the highest quartile was compared with the lowest. These results do not support an association between adipose tissue levels of DDE and DDT and breast cancer risk.
1994年至1997年在康涅狄格州进行了一项病例对照研究，以调查二氯二苯二氯乙烷（DDE）和二氯二苯三氯乙烷（DDT）暴露与乳腺癌风险之间的关系。病例和对照为40至79岁的女性，她们在耶鲁-纽黑文医院接受了与乳腺相关的手术，并且作者能够从其手术标本中获取至少0.4克乳腺脂肪组织用于化学分析。共有304例新发乳腺癌病例（包括62例原位癌）和186例良性乳腺疾病对照被纳入该研究。使用气相色谱法测量DDE和DDT的组织水平。使用方差分析和秩和检验计算DDE和DDT平均水平比较的统计学显著性。使用逻辑回归模型估计关联并控制混杂因素。病例组DDE的年龄调整几何平均组织水平（736.5 ppb）与对照组（784.1 ppb）相似。病例组（51.8 ppb）和对照组（55.6 ppb）的DDT水平也相似。当将最高四分位数与最低四分位数进行比较时，DDE的调整优势比为0.9（95%置信区间：0.5，1.5），DDT为0.8（95%置信区间：0.5，1.5）。这些结果不支持DDE和DDT的脂肪组织水平与乳腺癌风险之间存在关联。
