Chen R, Dick F, Seaton A
Department of Environmental and Occupational Medicine, Medical School, University of Aberdeen, Foresterhill, UK.
Occup Environ Med. 1999 Jun;56(6):383-7. doi: 10.1136/oem.56.6.383.
To study mortality and prevalence of neuropsychological symptoms among a cohort of painters known to have been heavily exposed to organic solvents.
A mortality study of 1292 male painters who had worked in a dockyard in Scotland for > or = 1 year between 1950 and 1992 comprised a nested cross sectional study of 953 surviving painters from the cohort and 953 male non-painters randomly selected from the local population and a case-control study of those with high symptom scores. Mortality, symptoms, and risks associated with painting, adjusting for age, education, smoking, alcohol, and personality were measured.
The proportional mortality ratio for all cancers was not increased significantly (110 (95% confidence interval (95% CI) 84 to 143), except for a possible excess of deaths from ischaemic heart disease (132, 105 to 164). Standardised mortality ratios were not significantly increased. Among the 260 surviving painters and 539 community controls who responded to the questionnaire there was a significant excess of symptoms among painters; adjusted relative risk (RR) increased significantly with increasing symptom score. These RRs suggested an exposure-response relation; for a high score (12-22) for all symptoms RR was 2.27 (1.20 to 4.30) for 1-4 years of exposure, 2.42 (1.18 to 4.95) for 5-9 years, 2.89 (1.42 to 5.88) for 10-14 years, and 3.41 (1.82 to 6.36) for 15-41 years, compared with controls. In multivariate analyses, painting exposure, and aging were associated with high symptom scores and there was again an increased risk relative to time worked as a painter.
This study supports the hypothesis that heavy and prolonged exposure to paint solvents leads to neuropsychological ill health.
研究一组已知大量接触有机溶剂的油漆工的死亡率和神经心理症状患病率。
对1950年至1992年间在苏格兰一个造船厂工作≥1年的1292名男性油漆工进行死亡率研究，其中包括对该队列中953名存活油漆工和从当地人群中随机选取的953名男性非油漆工进行的嵌套横断面研究，以及对症状评分高的人员进行的病例对照研究。测量了死亡率、症状以及与油漆工作相关的风险，并对年龄、教育程度、吸烟、饮酒和性格进行了校正。
所有癌症的比例死亡率未显著升高（110（95%置信区间（95%CI）84至143）），但缺血性心脏病死亡可能略有增加（132，105至164）。标准化死亡率未显著升高。在回复问卷的260名存活油漆工和539名社区对照中，油漆工的症状明显更多；校正后的相对风险（RR）随症状评分增加而显著升高。这些RR表明存在暴露-反应关系；所有症状评分高（12 - 22）时，暴露1 - 4年的RR为2.27（1.20至4.30），5 - 9年为2.42（1.18至4.95），10 - 14年为2.89（1.42至5.88），15 - 41年为3.41（1.82至6.36），与对照组相比。在多变量分析中，油漆暴露和衰老与高症状评分相关，并且相对于油漆工工作时间，风险再次增加。
本研究支持以下假设，即长期大量接触油漆溶剂会导致神经心理健康问题。
