Seo Sue-Ji, Shin Sae-Mi, Yoon Wonsuck, Byeon Sang-Hoon
Health and Safety Convergence Science Introduction, College of Health Science, Korea University, Seoul 02841, Republic of Korea.
Research Institute of Health Sciences, Korea University, Seoul 02841, Republic of Korea.
Toxics. 2024 Dec 11;12(12):903. doi: 10.3390/toxics12120903.
In the shipbuilding industry, during the painting process, workers are exposed to various substances in paint, including organic solvents that can adversely affect their health. Most workplace exposures to organic solvents involve mixtures of organic compounds. Therefore, in this study, the hazard quotient (HQ) and hazard index (HI) were derived using data from the Workplace Environmental Monitoring Program in Korea for six organic solvents (xylene, n-butanol, ethylbenzene, isobutyl alcohol, toluene, and methylisobutyl ketone [MIBK]) commonly used in the steel shipbuilding industry. The non-carcinogenic risk was assessed using Monte Carlo simulations, and sensitivity analysis was performed using the Spearman rank correlation coefficient with the R program. The HI for neurotoxicity and developmental toxicity exceeded 1 in the 25th and 75th percentile, respectively. According to the sensitivity analysis, the HI for neurotoxicity was correlated with the concentration of xylene and its exposure duration, whereas that for developmental toxicity was correlated with the concentration of ethylbenzene and MIBK and their exposure duration. This study investigated the health risks posed by organic solvents among workers involved in the painting process of shipbuilding. Additional research on percutaneous exposure to organic solvents and a detailed process analysis are needed.
在造船业中,在涂装过程中,工人会接触到涂料中的各种物质,包括可能对其健康产生不利影响的有机溶剂。大多数工作场所对有机溶剂的接触涉及有机化合物的混合物。因此,在本研究中,利用韩国工作场所环境监测计划的数据,得出了六种在钢制造船业中常用的有机溶剂(二甲苯、正丁醇、乙苯、异丁醇、甲苯和甲基异丁基酮[MIBK])的危害商数(HQ)和危害指数(HI)。使用蒙特卡罗模拟评估非致癌风险,并使用R程序通过斯皮尔曼等级相关系数进行敏感性分析。神经毒性和发育毒性的HI分别在第25和第75百分位数时超过1。根据敏感性分析,神经毒性的HI与二甲苯浓度及其暴露持续时间相关,而发育毒性的HI与乙苯和MIBK浓度及其暴露持续时间相关。本研究调查了造船涂装过程中工人接触有机溶剂所带来的健康风险。需要对有机溶剂的经皮暴露进行进一步研究,并进行详细的过程分析。