Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
作者信息
Vaidya B, Imrie H, Perros P, Dickinson J, McCarthy M I, Kendall-Taylor P, Pearce S H
出版信息
Lancet. 1999 Aug 28;354(9180):743-4. doi: 10.1016/S0140-6736(99)01465-8.
Abstract
Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.
摘要
Zotero 插件