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Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.

作者信息

Vaidya B, Imrie H, Perros P, Dickinson J, McCarthy M I, Kendall-Taylor P, Pearce S H

出版信息

Lancet. 1999 Aug 28;354(9180):743-4. doi: 10.1016/S0140-6736(99)01465-8.

DOI:10.1016/S0140-6736(99)01465-8
PMID:10475192
Abstract

Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.

摘要

相似文献

1
Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
Lancet. 1999 Aug 28;354(9180):743-4. doi: 10.1016/S0140-6736(99)01465-8.
2
CTLA-4 and HLA gene susceptibility to thyroid-associated orbitopathy.细胞毒性T淋巴细胞相关抗原4（CTLA-4）和人类白细胞抗原（HLA）基因与甲状腺相关眼病的易感性
Lancet. 1999 Nov 20;354(9192):1824. doi: 10.1016/S0140-6736(05)70596-1.
3
The influence of the exon 1 polymorphism of the cytotoxic T lymphocyte antigen 4 gene on thyroid antibody production in patients with newly diagnosed Graves' disease.细胞毒性T淋巴细胞抗原4基因第1外显子多态性对新诊断的格雷夫斯病患者甲状腺抗体产生的影响。
Thyroid. 2002 May;12(5):373-6. doi: 10.1089/105072502760043431.
4
Polymorphism in the promoter and exon 1 of the cytotoxic T lymphocyte antigen-4 gene associated with autoimmune thyroid disease in Koreans.细胞毒性T淋巴细胞抗原4基因启动子和外显子1的多态性与韩国人自身免疫性甲状腺疾病的相关性。
Thyroid. 2000 Jun;10(6):453-9. doi: 10.1089/thy.2000.10.453.
5
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus.细胞毒性T淋巴细胞相关抗原4（CTLA4）的丙氨酸-17赋予Graves病和1型糖尿病遗传易感性。
J Clin Endocrinol Metab. 1997 Jan;82(1):143-6. doi: 10.1210/jcem.82.1.3699.
6
Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology.对严重格雷夫斯眼病的遗传易感性有限：细胞毒性T淋巴细胞相关抗原4无作用，但有环境病因学证据。
Thyroid. 2000 Sep;10(9):791-8. doi: 10.1089/thy.2000.10.791.
7
Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations.欧洲和日本人群中细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因多态性及非遗传因素与格雷夫斯眼病的关联
Eur J Endocrinol. 2003 Jan;148(1):13-8. doi: 10.1530/eje.0.1480013.
8
Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis.细胞毒性T淋巴细胞抗原4（CTLA-4）基因多态性与1型自身免疫性肝炎易感性
Hepatology. 2000 Jan;31(1):49-53. doi: 10.1002/hep.510310110.
9
The immunogenetics of thyroid-associated orbitopathy.甲状腺相关性眼病的免疫遗传学
Exp Clin Endocrinol Diabetes. 1999;107 Suppl 5:S149-51. doi: 10.1055/s-0029-1212172.
10
CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism.细胞毒性T淋巴细胞相关抗原4（CTLA4）基因与格雷夫斯病：格雷夫斯病与CTLA4基因第1外显子和第1内含子多态性相关，但与启动子多态性无关。
Clin Endocrinol (Oxf). 2003 Jun;58(6):732-5. doi: 10.1046/j.1365-2265.2003.01778.x.

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