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淋巴组织中树突状细胞存在对膜淋巴毒素的需求。

The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues.

作者信息

Wu Q, Wang Y, Wang J, Hedgeman E O, Browning J L, Fu Y X

机构信息

Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA.

出版信息

J Exp Med. 1999 Sep 6;190(5):629-38. doi: 10.1084/jem.190.5.629.

DOI:10.1084/jem.190.5.629
PMID:10477548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195624/
Abstract

Although several cytokines, including tumor necrosis factor (TNF), can promote the growth of dendritic cells (DCs) in vitro, the cytokines that naturally regulate DC development and function in vivo have not been well defined. Here, we report that membrane lymphotoxin (LT), instead of TNF, regulates the migration of DCs in the spleen. LTalpha(-/-) mice, lacking membrane LTalpha/beta and LTalpha(3), show markedly reduced numbers of DCs in the spleen. Unlike wild-type mice and TNF(-/-) mice that have densely clustered DCs in the T cell zone and around the marginal zone, splenic DCs in LTalpha(-/-) mice are randomly distributed. The reduced number of DCs in lymphoid tissues of LTalpha(-/-) mice is associated with an increased number of DCs in nonlymphoid tissues. The number of splenic DCs in LTalpha(-/-) mice is restored when additional LT-expressing cells are provided. Blocking membrane LTalpha/beta in wild-type mice markedly diminishes the accumulation of DCs in lymphoid tissues. These data suggest that membrane LT is an essential ligand for the presence of DCs in the spleen. Mice deficient in TNF receptor, which is the receptor for both soluble LTalpha(3) and TNF-alpha(3) trimers, have normal numbers of DCs. However, LTbetaR(-/-) mice show reduced numbers of DCs, similar to the mice lacking membrane LT alpha/beta. Taken together, these results support the notion that the signaling via LTbetaR by membrane LTalpha/beta is required for the presence of DCs in lymphoid tissues.

摘要

尽管包括肿瘤坏死因子（TNF）在内的多种细胞因子可在体外促进树突状细胞（DC）的生长，但在体内自然调节DC发育和功能的细胞因子尚未明确界定。在此，我们报告膜淋巴毒素（LT）而非TNF调节脾脏中DC的迁移。缺乏膜LTα/β和LTα3的LTα（-/-）小鼠脾脏中的DC数量显著减少。与野生型小鼠和TNF（-/-）小鼠不同，野生型小鼠和TNF（-/-）小鼠的DC在T细胞区和边缘区周围密集聚集，而LTα（-/-）小鼠脾脏中的DC随机分布。LTα（-/-）小鼠淋巴组织中DC数量减少与非淋巴组织中DC数量增加有关。当提供额外表达LT的细胞时，LTα（-/-）小鼠脾脏中的DC数量得以恢复。在野生型小鼠中阻断膜LTα/β会显著减少淋巴组织中DC的聚集。这些数据表明膜LT是脾脏中DC存在的必需配体。缺乏TNF受体（可溶性LTα3和TNF-α3三聚体的受体）的小鼠DC数量正常。然而，LTβR（-/-）小鼠的DC数量减少，类似于缺乏膜LTα/β的小鼠。综上所述，这些结果支持以下观点，即膜LTα/β通过LTβR发出的信号是淋巴组织中DC存在所必需的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/984a373c6f15/JEM990534.f4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/c1869ef49bf5/JEM990534.f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/5f2b04d69d0d/JEM990534.f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/e95a5f23a776/JEM990534.f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/75ee5e8fe3aa/JEM990534.f6a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/db9cc9e5f181/JEM990534.f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/984a373c6f15/JEM990534.f4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/c1869ef49bf5/JEM990534.f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/5f2b04d69d0d/JEM990534.f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/e95a5f23a776/JEM990534.f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/75ee5e8fe3aa/JEM990534.f6a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/db9cc9e5f181/JEM990534.f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b9/2195624/984a373c6f15/JEM990534.f4a.jpg

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