Skottová N, Krecman V, Simánek V
Institute of Medical Chemistry, Medical Faculty, Palacký University, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
Phytother Res. 1999 Sep;13(6):535-7. doi: 10.1002/(sici)1099-1573(199909)13:6<535::aid-ptr526>3.0.co;2-w.
Silymarin, a standardized extract from Silybum marianum, inhibited in vitro the copper-induced oxidation of human LDL in a concentration-dependent manner. Silybin, a main flavonolignan of silymarin, appeared to be responsible for this LDL antioxidant effect. Silychristin and silydianin, other flavonolignans of silymarin, acted rather as pro-oxidants, but with regard to their content in silymarin, it did not contribute significantly to the reduction of the total LDL antioxidant capacity of silymarin.
水飞蓟素是从水飞蓟中提取的标准化提取物，它在体外以浓度依赖的方式抑制铜诱导的人低密度脂蛋白（LDL）氧化。水飞蓟宾是水飞蓟素的主要黄酮木脂素，似乎是这种LDL抗氧化作用的原因。水飞蓟亭和水飞蓟宁是水飞蓟素的其他黄酮木脂素，它们的作用更像是促氧化剂，但就它们在水飞蓟素中的含量而言，它们对水飞蓟素总LDL抗氧化能力的降低没有显著贡献。
