源自九带犰狳（Dasypus novemcinctus）的三株巴西副球孢子菌分离株的致病性和GP43kDa基因
Pathogenicities and GP43kDa gene of three Paracoccidioides brasiliensis isolates originated from a nine-banded armadillo (Dasypus novemcinctus).
作者信息
Sano A, Defaveri J, Tanaka R, Yokoyama K, Kurita N, Franco M, Coelho K I, Bagagli E, Montenegro M R, Miyaji M, Nishimura K
机构信息
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
出版信息
Mycopathologia. 1998;144(2):61-5. doi: 10.1023/a:1007024923042.
We studied three different isolates of Paracoccidioides brasiliensis obtained from the mesenteric lymph node (D3LY1), the spleen (D3S1) and the liver (D3LIV1) of the same armadillo (Dasypus novemcinctus). Pulmonal inflammatory area was evaluated by intravenous inoculation of 10(6) yeast cells of each isolates in young, male, ddY mice. Moreover, the partial sequence of GP43kDa gene of P. brasiliensis was analyzed. The lung inflammatory area was greater in animals inoculated with isolate D3S1. The partial sequence of GP43kDa gene indicated that isolate D3S1 is different from isolates D3LY1 and D3LIV1. This study suggested that the same armadillo might be susceptible to multiple P. brasiliensis isolates simultaneously.
我们研究了从同一只犰狳（九带犰狳）的肠系膜淋巴结（D3LY1）、脾脏（D3S1）和肝脏（D3LIV1）中获取的三种不同的巴西副球孢子菌分离株。通过给年轻的雄性ddY小鼠静脉注射每种分离株的10(6)个酵母细胞来评估肺部炎症区域。此外，还分析了巴西副球孢子菌GP43kDa基因的部分序列。接种分离株D3S1的动物肺部炎症区域更大。GP43kDa基因的部分序列表明，分离株D3S1与分离株D3LY1和D3LIV1不同。这项研究表明，同一只犰狳可能同时易受多种巴西副球孢子菌分离株的感染。
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