关注我们体重的重要性：非独立同胞对体重选择如何能极大地改变结果。

The importance of watching our weights: how the choice of weights for non-independent sib pairs can dramatically alter results.

作者信息

Van Eerdewegh P, Dupuis J, Santangelo S L, Hayward L B, Blacker D

机构信息

Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA.

出版信息

Genet Epidemiol. 1999;17 Suppl 1:S373-8. doi: 10.1002/gepi.1370170763.

DOI:10.1002/gepi.1370170763

PMID:10597465

Abstract

Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.

摘要

在有多个患病同胞的家庭中处理非独立同胞对，在基于似然性的非参数连锁分析中是一个问题。我们对比了MAPMAKER/SIBS中更稳定的部分似然解与ASPEX中使用的极易变的部分似然方法，以及像BETA中那样忽略该问题时对数优势比可能出现的膨胀。