回肠袋餐后运动反应的局部调节
Local regulation of postprandial motor responses in ileal pouches.
作者信息
Mularczyk A, Contessini-Avesani E, Cesana B, Bianchi P A, Basilisco G
机构信息
Cattedra di Gastroenterologia, Istituto di Scienze Mediche, Università degli Studi di Milano, Milan, Italy.
出版信息
Gut. 1999 Oct;45(4):575-80. doi: 10.1136/gut.45.4.575.
BACKGROUND
Local mechanisms are involved in the postprandial regulation of ileal tone in healthy subjects, but whether these mechanisms affect the postprandial tonic response of ileal pouches has not yet been investigated.
AIMS
To study the effect of a meal on pouch tone and phasic motor activity in patients with gut continuity or ileostomy and, in the latter group, the effect of a pouch perfusion with chyme or saline.
PATIENTS
Twenty patients with ileal pouches: 10 with gut continuity and 10 with ileostomy.
METHODS
Pouch tone and the frequency of phasic volume events were recorded with a barostat under fasting and postprandial conditions and after perfusion of the isolated pouch with chyme or saline.
RESULTS
The meal increased pouch tone and the frequency of phasic volume events in the patients with gut continuity, but not in those with ileostomy. Pouch perfusion with chyme induced a greater increase in pouch tone than saline.
CONCLUSIONS
The meal stimulated pouch tone and phasic motor activity. These effects were at least partially related to local pouch stimulation by intraluminal contents.
背景
局部机制参与健康受试者餐后回肠张力的调节，但这些机制是否影响回肠贮袋的餐后紧张性反应尚未得到研究。
目的
研究进餐对肠道连续性患者或回肠造口患者贮袋张力和阶段性运动活动的影响，以及在后一组患者中，向贮袋灌注食糜或生理盐水的影响。
患者
20例回肠贮袋患者，其中10例肠道具有连续性，10例为回肠造口患者。
方法
在禁食和餐后条件下，以及在用食糜或生理盐水灌注分离的贮袋后，用压力传感器记录贮袋张力和阶段性容量事件的频率。
结果
进餐增加了肠道具有连续性患者的贮袋张力和阶段性容量事件的频率，但未增加回肠造口患者的贮袋张力和阶段性容量事件的频率。用食糜灌注贮袋比用生理盐水灌注引起的贮袋张力增加更大。
结论
进餐刺激了贮袋张力和阶段性运动活动。这些效应至少部分与腔内内容物对局部贮袋的刺激有关。
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