Lunding S, Hansen K S, Krogsgaard K, Rosdahl N, Smith E, Wantzin P S
H:S Amager Hospital, HBA, medicinsk afdeling, BST Københavns Kommune.
Ugeskr Laeger. 1999 Aug 2;161(31):4393-6.
The objective of this study was to examine whether the prevalence of hepatitis C, like hepatitis B, is increased among the mentally retarded in Denmark. The prevalence of serological markers of hepatitis B and C was examined in an institution for the mentally retarded. A total of 126 out of 178 inhabitants (71%) with a median age of 49 years (range 23-78) participated. All subjects were anti-HCV-negative by third generation ELISA antibody test. A total of 45 (35.7%) subjects were anti-HBc-positive and 10 (7.9%) were HBsAg-positive. Among subjects with Down's syndrome (n = 20), 55% were anti-HBc-positive and 30% were HBsAg-positive as compared to 32% and 3.8% respectively among others. In conclusion, hepatitis C infection seems to be uncommon among mentally retarded persons in Denmark and the risk of acquiring infection not significantly increased as compared to that of the general population. The prevalence of serological markers for hepatitis B was high and comparable to previous studies in this population.
本研究的目的是调查丹麦智障人群中丙型肝炎的患病率是否如乙型肝炎那样有所增加。在一所智障人士机构中对乙型和丙型肝炎血清学标志物的患病率进行了检测。178名居民中共有126人（71%）参与，年龄中位数为49岁（范围23 - 78岁）。通过第三代ELISA抗体检测，所有受试者抗-HCV均为阴性。共有45名（35.7%）受试者抗-HBc阳性，10名（7.9%）HBsAg阳性。在唐氏综合征患者（n = 20）中，55%抗-HBc阳性，30% HBsAg阳性，而其他人群中这一比例分别为32%和3.8%。总之，丹麦智障人群中丙型肝炎感染似乎并不常见，与普通人群相比，感染风险没有显著增加。乙型肝炎血清学标志物的患病率较高，与该人群先前的研究结果相当。
