Doty R L, Li C, Mannon L J, Yousem D M
Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Neurology. 1999 Sep 11;53(4):880-2. doi: 10.1212/wnl.53.4.880.
Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.
在18至20个月的时间里，对5名多发性硬化症患者中的每一位，在三到四个不同时间点获取了宾夕法尼亚大学嗅觉识别测试（UPSIT）的分数，以及通过磁共振成像（MRI）确定的额下回和颞叶内斑块数量。纵向观察发现，斑块数量的缓解和加重与UPSIT分数之间存在密切关联，斑块越多，UPSIT分数越低。这些观察结果进一步支持了以下假设：多发性硬化症中的嗅觉丧失与中枢嗅觉脑区斑块数量的波动有关。
