Chang C, Shockey J A
Department of Cell Biology and Molecular Genetics, Maryland Agricultural Experiment Station, HJ Patterson Hall, University of Maryland, College Park, MD 20742, USA.
Curr Opin Plant Biol. 1999 Oct;2(5):352-8. doi: 10.1016/s1369-5266(99)00004-7.
Tremendous strides have been made in the past year toward elucidating the ethylene-response pathway. Ethylene is perceived by a family of histidine kinase-like receptors, which negatively regulate ethylene responses. Binding of ethylene requires a copper cofactor, and proper receptor function relies on a copper transporter. Downstream, EIN2 is a structurally novel protein containing an integral membrane domain. In the nucleus, the EIN3 family of DNA-binding proteins regulates transcription in response to ethylene, and an immediate target of EIN3 is a DNA-binding protein of the AP2/EREBP family.
在过去的一年里，我们在阐明乙烯反应途径方面取得了巨大进展。乙烯由一组类组氨酸激酶受体感知，这些受体对乙烯反应起负调控作用。乙烯的结合需要铜辅因子，而受体的正常功能依赖于一种铜转运蛋白。在下游，EIN2是一种结构新颖的蛋白质，含有一个完整的膜结构域。在细胞核中，EIN3家族的DNA结合蛋白响应乙烯调节转录，EIN3的一个直接靶点是AP2/EREBP家族的一种DNA结合蛋白。
