由磷脂酰胆碱和聚氧乙烯烷基醚组成的特定混合脂质体对体外肿瘤细胞生长具有显著增强的抑制作用。

Specific hybrid liposomes composed of phosphatidylcholine and polyoxyethylenealkyl ether with markedly enhanced inhibitory effects on the growth of tumor cells in vitro.

作者信息

Matsumoto Y, Imamura C, Ito T, Taniguchi C, Ueoka R

机构信息

Department of Industrial Chemistry, Faculty of Engineering, Kumamoto Institute of Technology, Japan.

出版信息

Biol Pharm Bull. 1995 Oct;18(10):1456-8. doi: 10.1248/bpb.18.1456.

DOI:10.1248/bpb.18.1456

PMID:8593457

Abstract

The hybrid liposomes (90mol% DMPC/10mol% C12(EO)8 and 90mol% DMPC/10mol% C12(EO)12) have a highly inhibitory action against the growth of tumor cells. The uniform and stable structure of the hybrid liposomes was revealed on the basis of electron microscopy and dynamic light scattering measurements.

摘要

混合脂质体（90摩尔％二肉豆蔻酰磷脂酰胆碱/10摩尔％C12(EO)8和90摩尔％二肉豆蔻酰磷脂酰胆碱/10摩尔％C12(EO)12）对肿瘤细胞的生长具有高度抑制作用。基于电子显微镜和动态光散射测量揭示了混合脂质体均匀且稳定的结构。