Maren S
Dept of Psychology and Neuroscience Program, University of Michigan, MI 48109-1109, USA.
Trends Neurosci. 1999 Dec;22(12):561-7. doi: 10.1016/s0166-2236(99)01465-4.
In the mammalian brain, LTP is an enduring form of synaptic plasticity that is posited to have a role in learning and memory. Compelling new evidence for this view derives from studies of LTP in the amygdala, a brain structure that is essential for simple forms of emotional learning and memory, such as Pavlovian fear conditioning in rats. More specifically, antagonists of the NMDA receptor block both amygdaloid LTP induction and fear conditioning, fear conditioning induces increases in amygdaloid synaptic transmission that resemble LTP, and genetic modifications that disrupt amygdaloid LTP eliminate fear conditioning. Collectively, these results provide the most-convincing evidence to date that LTP mediates learning and memory in mammals.
在哺乳动物大脑中，长时程增强（LTP）是一种持久的突触可塑性形式，被认为在学习和记忆中发挥作用。这一观点的有力新证据来自对杏仁核中LTP的研究，杏仁核是一种对简单形式的情绪学习和记忆（如大鼠的巴甫洛夫恐惧条件反射）至关重要的脑结构。更具体地说，NMDA受体拮抗剂会阻断杏仁核LTP的诱导和恐惧条件反射，恐惧条件反射会诱导杏仁核突触传递增加，类似于LTP，而破坏杏仁核LTP的基因修饰会消除恐惧条件反射。总体而言，这些结果提供了迄今为止最有说服力的证据，表明LTP介导哺乳动物的学习和记忆。
