耐万古霉素屎肠球菌对奎奴普丁-达福普汀与其他抗菌药物联合使用的协同性测试。
Synergy testing of vancomycin-resistant Enterococcus faecium against quinupristin-dalfopristin in combination with other antimicrobial agents.
作者信息
Matsumura S O, Louie L, Louie M, Simor A E
机构信息
Department of Microbiology, SD Laboratory Services, Sunnybrook and Women's College Health Sciences Centre, North York, Canada.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2776-9. doi: 10.1128/AAC.43.11.2776.
Abstract
Using checkerboard and time-kill assays, we evaluated the in vitro activity of quinupristin-dalfopristin (RP 59500) alone and in combination with five other antimicrobial agents against 12 clinical strains of vancomycin-resistant Enterococcus faecium (VREF). In time-kill studies, six VREF strains exhibited synergism with the combination of quinupristin-dalfopristin and doxycycline and three exhibited synergism with quinupristin-dalfopristin plus ampicillin-sulbactam. Combinations of quinupristin-dalfopristin with these and other agents warrant further clinical evaluation for the treatment of serious VREF infections.
摘要
我们采用棋盘法和时间杀菌试验，评估了单独使用喹奴普丁-达福普汀（RP 59500）以及将其与其他五种抗菌药物联合使用时，对12株耐万古霉素屎肠球菌（VREF）临床菌株的体外活性。在时间杀菌研究中，6株VREF菌株对喹奴普丁-达福普汀与强力霉素的联合用药表现出协同作用，3株对喹奴普丁-达福普汀加氨苄西林-舒巴坦表现出协同作用。喹奴普丁-达福普汀与这些及其他药物的联合用药，值得进一步进行临床评估，以用于治疗严重的VREF感染。
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本文引用的文献
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