马疱疹病毒3型（EHV3）糖蛋白G同源物的核苷酸序列表明，EHV3是一种独特的马属α疱疹病毒。

The nucleotide sequence of the glycoprotein G homologue of equine herpesvirus 3 (EHV3) indicates EHV3 is a distinct equid alphaherpesvirus.

作者信息

Hartley C A, Drummer H E, Studdert M J

机构信息

Centre for Equine Virology, School of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.

出版信息

Arch Virol. 1999;144(10):2023-33. doi: 10.1007/s007050050723.

DOI:10.1007/s007050050723

PMID:10550674

Abstract

EHV3 causes equine coital exanthema and has been classified as an alphaherpesvirus on the basis of its biological properties; however due to the absence of any sequence information the phylogenetic relationship has not previously been examined. The complete nucleotide sequence of the EHV3 glycoprotein G (gG) gene was determined and showed that this virus is most closely related to the alphaherpesviruses equine herpesviruses type 1 (EHV 1) and type 4 (EHV4). EHV3 gG contains conserved and variable regions which are homologous to those previously defined for EHV1 and EHV4 gG proteins. Consistent with EHV1 and EHV4 gG, the variable region of EHV3 gG was found to elicit a strong antibody response in experimentally and naturally infected horses and could be exploited for use as a diagnostic reagent.

摘要

马疱疹病毒3型（EHV3）可引起马交媾疹，根据其生物学特性已被归类为α疱疹病毒；然而，由于缺乏任何序列信息，此前尚未对其系统发育关系进行研究。测定了EHV3糖蛋白G（gG）基因的完整核苷酸序列，结果表明该病毒与α疱疹病毒1型马疱疹病毒（EHV 1）和4型马疱疹病毒（EHV4）关系最为密切。EHV3 gG包含保守区和可变区，这些区域与先前为EHV1和EHV4 gG蛋白定义的区域同源。与EHV1和EHV4 gG一致，发现EHV3 gG的可变区在实验感染和自然感染的马匹中引发强烈的抗体反应，可作为诊断试剂加以利用。