两类翻译控制RNA：它们在蛋白质合成调控中的作用。
Two classes of translational control RNA: their role in the regulation of protein synthesis.
作者信息
Bester A J, Kennedy D S, Heywood S M
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1523-7. doi: 10.1073/pnas.72.4.1523.
Abstract
Two classes of translation control RNA (tcRNA) have been isolated from embryonic chick muscle. One of these classes, the tcRNA isolated from messenger ribonucleoprotein particles (mRNP-tcRNA), is effective in inhibiting the translation of mRNP-mRNA while having little if any effect on polysomal mRNA. The other class, polysome-tcRNA, has no effect on mRNP-mRNA while it stimulates the translation of polysomal mRNA. The mRNP tcRNA contains approximately 50 percent uridylate residues and forms small but stable hybrids with poly (A), while polysome-tcRNA contains fewer uridylate residues and is much less effective in forming a hybrid with poly (A). A proposed model concerning the role of these two classes of tcRNA in the regulation of protein synthesis is presented.
摘要
已从鸡胚胎肌肉中分离出两类翻译控制RNA（tcRNA）。其中一类是从信使核糖核蛋白颗粒（mRNP-tcRNA）中分离出的tcRNA，它能有效抑制mRNP-mRNA的翻译，而对多聚核糖体mRNA几乎没有影响。另一类是多聚核糖体-tcRNA，它对mRNP-mRNA没有影响，但能刺激多聚核糖体mRNA的翻译。mRNP tcRNA含有约50%的尿苷酸残基，并能与聚腺苷酸（poly (A)）形成小而稳定的杂交体，而多聚核糖体-tcRNA含有的尿苷酸残基较少，与聚腺苷酸形成杂交体的效率也低得多。本文提出了一个关于这两类tcRNA在蛋白质合成调控中作用的模型。
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