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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lehner T, Russell M W, Wilton J M, Challacombe S J, Scully C M, Hawkes J E

Adv Exp Med Biol. 1978;107:303-15. doi: 10.1007/978-1-4684-3369-2_35.

The immunological mechanism of protection against dental caries has been investigated by passive immunization with antisera to S. mutans in the rhesus monkey. 2) Passive immunization with separated IgG, IgM and IgA from sera of immunized monkeys supports the concept that IgG, unlike IgA or IgM antibodies are protective. 3) The role of cell-mediated immunity has been explored by the use of transfer factor. This showed that protection against dental caries can be elicited by passive transfer of whole immune serum and cellular immunity, but not by cellular immunity or immune serum alone. 4) The results of active and passive immunization suggests that immuno-regulation of T and B cell interactions plays an important part in the effector mechanism of opsonization, phagocytosis and killing of S. mutans.

通过用抗变形链球菌抗血清对恒河猴进行被动免疫，研究了预防龋齿的免疫机制。2) 用免疫猴血清中分离出的IgG、IgM和IgA进行被动免疫，支持了与IgA或IgM抗体不同，IgG具有保护作用的观点。3) 通过使用转移因子探索了细胞介导免疫的作用。这表明，通过被动转移全免疫血清和细胞免疫可引发对龋齿的保护作用，但单独的细胞免疫或免疫血清则不能。4) 主动免疫和被动免疫的结果表明，T细胞和B细胞相互作用的免疫调节在调理、吞噬和杀死变形链球菌的效应机制中起重要作用。

Lehner T, Russell M W, Wilton J M, Challacombe S J, Scully C M, Hawkes J E

Adv Exp Med Biol. 1978;107:303-15. doi: 10.1007/978-1-4684-3369-2_35.

The immunological mechanism of protection against dental caries has been investigated by passive immunization with antisera to S. mutans in the rhesus monkey. 2) Passive immunization with separated IgG, IgM and IgA from sera of immunized monkeys supports the concept that IgG, unlike IgA or IgM antibodies are protective. 3) The role of cell-mediated immunity has been explored by the use of transfer factor. This showed that protection against dental caries can be elicited by passive transfer of whole immune serum and cellular immunity, but not by cellular immunity or immune serum alone. 4) The results of active and passive immunization suggests that immuno-regulation of T and B cell interactions plays an important part in the effector mechanism of opsonization, phagocytosis and killing of S. mutans.

通过用抗变形链球菌抗血清对恒河猴进行被动免疫，研究了预防龋齿的免疫机制。2) 用免疫猴血清中分离出的IgG、IgM和IgA进行被动免疫，支持了与IgA或IgM抗体不同，IgG具有保护作用的观点。3) 通过使用转移因子探索了细胞介导免疫的作用。这表明，通过被动转移全免疫血清和细胞免疫可引发对龋齿的保护作用，但单独的细胞免疫或免疫血清则不能。4) 主动免疫和被动免疫的结果表明，T细胞和B细胞相互作用的免疫调节在调理、吞噬和杀死变形链球菌的效应机制中起重要作用。