Lehner T, Challacombe S J, Caldwell J
Immunology. 1980 Dec;41(4):857-64.
The oral route of immunization with Streptococcus mutants was compared with the subcutaneous route in rhesus monkeys. Significant levels of serum IgG, IgM and IgA antibodies in Strep. mutans were elicited only in monkeys immunized subcutaneously. Similarly, the skin delayed hypersensitivity reaction to Strep. mutans was elicited only in the subcutaneously immunized monkeys. Oral immunization induced a modest increase in salivary IgA antibodies to Strep. mutans, though a slight increase in IgA antibodies was also found in the saliva of all other groups of immunized and control monkeys. A small though not significant reduction in dental caries was found in the monkeys immunized orally, whereas subcutaneous immunization with Strep. mutans consistently elicited a significant reduction in caries. Oral feeding of Strep. mutans failed to induce tolerance to a subsequent subcutaneous challenge by the same organism. Furthermore, sequential subcutaneous followed by oral immunization had little effect on the titre of salivary or serum antibodies.
在恒河猴中，比较了用变形链球菌进行口服免疫与皮下免疫的效果。仅在皮下免疫的猴子中诱导出了变形链球菌血清IgG、IgM和IgA抗体的显著水平。同样，对变形链球菌的皮肤迟发型超敏反应也仅在皮下免疫的猴子中出现。口服免疫诱导了唾液中针对变形链球菌的IgA抗体适度增加，不过在所有其他免疫组和对照组猴子的唾液中也发现了IgA抗体的轻微增加。口服免疫的猴子中龋齿有轻微但不显著的减少，而用变形链球菌进行皮下免疫则始终能显著减少龋齿。口服变形链球菌未能诱导对同一菌株随后皮下攻击的耐受性。此外，先进行皮下免疫再进行口服免疫对唾液或血清抗体滴度几乎没有影响。
