Lehner T, Russell M W, Challacombe S J, Scully C M, Hawkes J E
Lancet. 1978 Apr 1;1(8066):693-5. doi: 10.1016/s0140-6736(78)90803-6.
Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.
用变形链球菌进行主动免疫可诱导恒河猴预防龋齿，这与血清抗体有关。将含有针对变形链球菌的IgG、IgM和IgA抗体的免疫血清进行被动转移，未能诱导预防龋齿。然而，当给予分离的IgG、IgM和IgA血清时，IgG可诱导显著的保护作用，但针对变形链球菌的IgA或IgM抗体则不能。IgA和IgM可能会竞争或干扰IgG抗体的保护作用，IgG/IgA和IgG/IgM抗体的比例可能是预防龋齿免疫中的一个重要因素。
