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恒河猴体内的苯乙胺:与α-甲基对酪氨酸和左旋多巴的相互作用

Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa.

作者信息

Tinklenberg J R, Gillin J C, Murphy G M, Staub R, Wyatt R J

出版信息

Am J Psychiatry. 1979 Mar;136(3):311-3. doi: 10.1176/ajp.136.3.311.

DOI:10.1176/ajp.136.3.311
PMID:105644
Abstract

Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.

摘要

用α-甲基-对-酪氨酸(AMPT)预处理恒河猴,随后注射苯乙胺(PEA),未表现出典型的苯丙胺样PEA效应。然而,当AMPT预处理后接着给予左旋多巴,然后注射PEA时,PEA效应得以恢复。这些结果与精神分裂症的多巴胺理论相符。

相似文献

1
Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa.恒河猴体内的苯乙胺:与α-甲基对酪氨酸和左旋多巴的相互作用
Am J Psychiatry. 1979 Mar;136(3):311-3. doi: 10.1176/ajp.136.3.311.
2
The effects of phenylethylamine in rhesus monkeys.苯乙胺对恒河猴的影响。
Am J Psychiatry. 1978 May;135(5):576-8. doi: 10.1176/ajp.135.5.576.
3
Monoamine oxidase inhibitors potentiate phenylethylamine effects in rhesus monkeys.单胺氧化酶抑制剂可增强恒河猴体内苯乙胺的作用。
Biol Psychiatry. 1980 Jun;15(3):429-36.
4
Dose-response effects of beta-phenylethylamine on stereotyped behavior in pargyline-pretreated rats.β-苯乙胺对帕吉林预处理大鼠刻板行为的剂量反应效应。
Biol Psychiatry. 1976 Dec;11(6):731-42.
5
A new animal model for schizophrenia: interactions with adrenergic mechanisms.
Biol Psychiatry. 1978 Apr;13(2):217-25.
6
Trace amines inhibit the electrically evoked release of [3H]acetylcholine from slices of rat striatum in the presence of pargyline: similarities between beta-phenylethylamine and amphetamine.在存在帕吉林的情况下,痕量胺抑制大鼠纹状体切片中[3H]乙酰胆碱的电诱发释放:β-苯乙胺与苯丙胺之间的相似性。
J Pharmacol Exp Ther. 1985 Oct;235(1):220-9.
7
Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine.痕量胺β-苯乙胺的多巴胺转运体依赖性和非依赖性作用
J Neurochem. 2004 Oct;91(2):362-73. doi: 10.1111/j.1471-4159.2004.02721.x.
8
Comparison of behavioral effects of systemic L-DOPA and intracranial dopamine in mesolimbic forebrain of nonhuman primates.非人类灵长类动物中脑边缘前脑系统左旋多巴与颅内多巴胺行为效应的比较。
Pharmacol Biochem Behav. 1979 May;10(5):711-6. doi: 10.1016/0091-3057(79)90323-x.
9
Effect of chronic cocaine on behavior and cyclic AMP in cerebrospinal fluid of rhesus monkeys.
Commun Psychopharmacol. 1979;3(3):143-52.
10
[Antagonism between L-DOPA and apomorphine in their effects on rat behavior].[左旋多巴与阿扑吗啡对大鼠行为影响的拮抗作用]
Biull Eksp Biol Med. 1977 Jul;84(7):51-3.

引用本文的文献

1
A study on the acute effect of amphetamine on the urinary excretion of biogenic amines and metabolites in monkeys.一项关于苯丙胺对猴子生物胺及其代谢产物尿排泄的急性影响的研究。
Br J Pharmacol. 1981 Nov;74(3):571-7. doi: 10.1111/j.1476-5381.1981.tb10466.x.