恒河猴体内的苯乙胺：与α-甲基对酪氨酸和左旋多巴的相互作用
Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa.
作者信息
Tinklenberg J R, Gillin J C, Murphy G M, Staub R, Wyatt R J
出版信息
Am J Psychiatry. 1979 Mar;136(3):311-3. doi: 10.1176/ajp.136.3.311.
PMID:105644
Abstract
Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.
摘要
用α-甲基-对-酪氨酸（AMPT）预处理恒河猴，随后注射苯乙胺（PEA），未表现出典型的苯丙胺样PEA效应。然而，当AMPT预处理后接着给予左旋多巴，然后注射PEA时，PEA效应得以恢复。这些结果与精神分裂症的多巴胺理论相符。
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