Zerosi C, Giardino L, Lafornara D, Scarola V
Gruppo di Studio Nuova endodonzia, Università degli Studi, Pavia.
Minerva Stomatol. 1999 Jul-Aug;48(7-8):307-10.
The aim of this study was to evaluate the presence of Russell bodies in chronically inflamed pulp using histological methods.
The authors analysed 20 samples: 18 were teeth or pulp from subjects suffering from chronic pulpar diseases and 2 were teeth extracted for orthodontic reasons showing no signs of pulpar disease.
Russell bodies were found in the majority of samples examined, both inside the plasma cells and in pulpar stroma. Russell bodies were not present in samples affected by acute phlogistic processes, with a prevalence of neutrophil granulocytes in the pulp structure, and not in elements free from pulpar disease.
As already reported in earlier studies of periapical lesions, also in this case the irritative stimulus caused by the bacteria present in chronically inflamed pulp leads to the hyperactivation of plasma cells and the consequent hyperproduction of immunoglobulins.
本研究旨在运用组织学方法评估慢性炎症牙髓中拉塞尔小体的存在情况。
作者分析了20个样本：18个是患有慢性牙髓疾病受试者的牙齿或牙髓，2个是因正畸原因拔除且无牙髓疾病迹象的牙齿。
在所检查的大多数样本中，无论是在浆细胞内还是牙髓基质中均发现了拉塞尔小体。在受急性炎症过程影响的样本中未发现拉塞尔小体，这些样本的牙髓结构中以中性粒细胞为主，且在无牙髓疾病的样本中也未发现。
正如先前关于根尖周病变的研究所报道的那样，在这种情况下，慢性炎症牙髓中存在的细菌所引起的刺激也会导致浆细胞过度活化，进而导致免疫球蛋白过度产生。
