McDonnell W F, Stewart P W, Smith M V, Pan W K, Pan J
Human Studies Division, NHEERL, U.S. Environmental Protection Agency, RTP, NC 27599-7315, USA.
Eur Respir J. 1999 Oct;14(4):845-53. doi: 10.1034/j.1399-3003.1999.14d21.x.
Ozone-induced respiratory symptoms are known to be functions of concentration, minute ventilation, and duration of exposure. The purposes of this study were to identify an exposure-response model for symptoms, to determine whether response was related to age, and to assess the relationships between symptom and lung function responses to ozone. Four hundred and eighty-five healthy male volunteers (ages 18-35 yrs) were exposed to one of six ozone concentrations at one of three activity levels for 2 h. Symptoms and forced expiratory volume in one second (FEV1) were assessed at the end of 1 and 2 h. The exposure and response data were fitted by a nonlinear exposure-response model previously found to describe FEV1 response. The proportion of individuals experiencing moderate or severe cough, shortness of breath, and pain on deep inspiration were accurately described as functions of concentration, minute ventilation, and time. Response was inversely related to age for shortness of breath (p=0.0001), pain on deep inspiration (p=0.0002), and cough (p=0.0013). Controlling for exposure differences, symptom responses were significantly but weakly (correlation coefficient 0.30-0.41) related to the FEV1 response. In conclusion, the exposure-response model did accurately predict symptoms, response was inversely related to age.
已知臭氧诱发的呼吸道症状是浓度、分钟通气量和暴露持续时间的函数。本研究的目的是确定症状的暴露-反应模型，确定反应是否与年龄有关，并评估症状与臭氧肺功能反应之间的关系。485名健康男性志愿者（年龄18 - 35岁）在三种活动水平之一的情况下暴露于六种臭氧浓度之一，持续2小时。在1小时和2小时结束时评估症状和一秒用力呼气量（FEV1）。暴露和反应数据通过先前发现可描述FEV1反应的非线性暴露-反应模型进行拟合。经历中度或重度咳嗽、呼吸急促和深吸气疼痛的个体比例被准确地描述为浓度、分钟通气量和时间的函数。呼吸急促（p = 0.0001）、深吸气疼痛（p = 0.0002）和咳嗽（p = 0.0013）的反应与年龄呈负相关。在控制暴露差异的情况下，症状反应与FEV1反应显著但微弱相关（相关系数0.30 - 0.41）。总之，暴露-反应模型确实准确预测了症状，反应与年龄呈负相关。
