Juniper E F, O'Byrne P M, Guyatt G H, Ferrie P J, King D R
Dept of Clinical Epidemiology and Biostatistics, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.
Eur Respir J. 1999 Oct;14(4):902-7. doi: 10.1034/j.1399-3003.1999.14d29.x.
International guidelines on asthma management indicate that the primary goal of treatment should be optimum asthma control. The aim of this study was to develop and validate the Asthma Control Questionnaire (ACQ). The authors generated a list of all symptoms used to assess control and sent it to 100 asthma clinicians who were members of guidelines committees (18 countries). They scored each symptom for its importance in evaluating asthma control. From the 91 responses, the five highest scoring symptoms were selected for the ACQ. In addition, there is one question on beta2-agonist use and another on airway calibre (total questions=7). The ACQ was tested in a 9-week observational study of 50 adults with symptomatic asthma. The ACQ and other measures of asthma health status were assessed at baseline, 1, 5 and 9 weeks. In patients whose asthma was stable between clinic visits, reliability of the ACQ was high (intraclass correlation coefficient (ICC)=0.90). The questionnaire was very responsive to change in asthma control (p<0.0001). Cross-sectional and longitudinal validity were supported by correlations between the ACQ and other measures of asthma health status being close to a priori predictions. In conclusion, the Asthma Control Questionnaire has strong evaluative and discriminative properties and can be used with confidence to measure asthma control.
国际哮喘管理指南指出，治疗的主要目标应是实现最佳哮喘控制。本研究的目的是开发并验证哮喘控制问卷（ACQ）。作者列出了所有用于评估控制情况的症状清单，并将其发送给100位担任指南委员会成员的哮喘临床医生（来自18个国家）。他们就每种症状在评估哮喘控制中的重要性进行评分。从91份回复中，为ACQ选出了得分最高的5种症状。此外，还有一个关于β2激动剂使用的问题以及另一个关于气道口径的问题（问题总数 = 7个）。在一项对50名有症状哮喘成年患者进行的为期9周的观察性研究中对ACQ进行了测试。在基线、第1、5和9周时对ACQ及其他哮喘健康状况指标进行了评估。在门诊就诊期间哮喘病情稳定的患者中，ACQ的可靠性很高（组内相关系数（ICC）= 0.90）。该问卷对哮喘控制的变化反应非常灵敏（p < 0.0001）。ACQ与其他哮喘健康状况指标之间的相关性接近先验预测，从而支持了横断面和纵向效度。总之，哮喘控制问卷具有很强的评估和鉴别特性，可以放心地用于衡量哮喘控制情况。
