Scranton P E, McMaster J H, Kenny F M, Foley T P, Taylor F H
J Surg Oncol. 1975;7(5):403-9. doi: 10.1002/jso.2930070511.
Altered carbohydrate metabolism associated with fibrosarcomas and chondrosarcomas has been well-documented in past literature. This report describes abnormal carbohydrate metabolism in 2 osteosarcoma patients, and abnormalities in growth hormone and somatomedin serum levels. Experimental evidence is presented showing in vitro suppression of osteosarcoma tumor cell proliferation by 17 beta Estradiol. Estrogen inhibition of linear bone growth, cartilage proliferation, and somatomedin is discussed with reference to possible estrogen therapy in osteosarcoma.
过去的文献中已充分记载了与纤维肉瘤和软骨肉瘤相关的碳水化合物代谢改变。本报告描述了2例骨肉瘤患者的碳水化合物代谢异常，以及生长激素和生长调节素血清水平的异常。提供了实验证据，表明17β-雌二醇在体外可抑制骨肉瘤肿瘤细胞增殖。结合骨肉瘤可能的雌激素治疗，讨论了雌激素对线性骨生长、软骨增殖和生长调节素的抑制作用。
