Marlow A J, John S, Worthington J
ARC Epidemiology Research Unit, University of Manchester, England.
Genet Epidemiol. 1997;14(6):845-50. doi: 10.1002/(SICI)1098-2272(1997)14:6<845::AID-GEPI47>3.0.CO;2-N.
Complete multipoint analysis as implemented by MAPMAKER/SIBS was used to identify the chromosomal regions with the strongest evidence of linkage. Three different quantitative sib-pair methods were compared. For each trait the maximum lod/Z score was used to implicate a chromosomal region. For trait Q5, chromosome 5, the analysis was repeated in a second data set to test for replication of the result from the first data set. The initial screen was carried out using complete parental information and the first sibling pair from each nuclear family. The effect of removing the parental genotypes and the use of multiple independent sibs was examined in the second data set for Q5, chromosome 5.
采用由MAPMAKER/SIBS实现的完整多点分析来识别具有最强连锁证据的染色体区域。比较了三种不同的定量同胞对方法。对于每个性状，使用最大对数优势比/ Z分数来确定一个染色体区域。对于性状Q5（位于5号染色体），在第二个数据集中重复进行分析以检验第一个数据集结果的可重复性。初始筛选使用完整的亲本信息以及每个核心家庭的第一对同胞。在第二个数据集中对位于5号染色体的性状Q5检验了去除亲本基因型以及使用多个独立同胞的效果。
