Aplin A E, Howe A K, Juliano R L
Department of Pharmacology, School of Medicine, University of North Carolina, NC 27599, USA.
Curr Opin Cell Biol. 1999 Dec;11(6):737-44. doi: 10.1016/s0955-0674(99)00045-9.
Signals from dynamic cellular interactions between the extracellular matrix and neighboring cells ultimately input into the cellular decision-making process. These interactions form the basis of anchorage-dependent growth. Recent advances have provided the mechanistic details behind the ability of integrins, and other cell adhesion molecules (CAMs), to regulate both early signal transduction events initiated by soluble factors and downstream events more proximally involved in cell cycle progression. These actions appear to depend on the ability of CAMs to initiate the formation of organized structures that permit the efficient flow of information.
细胞外基质与邻近细胞之间动态细胞相互作用产生的信号最终输入到细胞决策过程中。这些相互作用构成了锚定依赖性生长的基础。最近的进展揭示了整合素及其他细胞粘附分子（CAMs）调节由可溶性因子引发的早期信号转导事件以及更直接参与细胞周期进程的下游事件的机制细节。这些作用似乎取决于细胞粘附分子启动有序结构形成的能力，而这种有序结构能够实现信息的高效传递。
