转动轮：稳态研究
The turning wheel: a study in steady states.
作者信息
Wyman J
出版信息
Proc Natl Acad Sci U S A. 1975 Oct;72(10):3983-7. doi: 10.1073/pnas.72.10.3983.
Subject to the limitation of one-step transitions, a system composed of a polyfunctional macromolecule (say a polyfunctional enzyme), present in fixed amount together with its ligands (substrates) in a fixed volume, can be represented by an r-dimensional cube of which each of the 2r corners corresponds to one of the microscopically different forms. In the steady state we may predict circulation of the macromolecule around the edges of the cube. This would provide a molecular mechanism whereby one enzymatic reaction could drive another, the enzyme itself acting as a transducer. Such a system is asymptotically stable and subject to a set of linkage relations derivable by the cofactor principle from the steady state equations.
在一步转移的限制条件下，一个由多官能大分子（比如多官能酶）组成的系统，与它的配体（底物）以固定量存在于固定体积中，可以用一个r维立方体来表示，其中2r个角中的每一个都对应一种微观上不同的形式。在稳态下，我们可以预测大分子在立方体边缘的循环。这将提供一种分子机制，借此一个酶促反应可以驱动另一个反应，酶本身充当一个转换器。这样一个系统是渐近稳定的，并且服从一组可由稳态方程通过辅助因子原理推导出来的连锁关系。
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