Girvin B, McDermott B J, Johnston G D
Department of Therapeutics and Pharmacology, The Queen's University of Belfast, UK.
J Hypertens. 1999 Nov;17(11):1627-31. doi: 10.1097/00004872-199917110-00017.
To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.
Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.
General practices in the greater Belfast and Lisburn area in Northern Ireland.
Twenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.
Reduction in blood pressure and estimation of patient compliance.
Patient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.
Enalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance.
比较每日一次服用20毫克依那普利与每日两次服用10毫克依那普利在降低血压及患者依从性方面的效果。
在为期4周的安慰剂导入期后，对患者进行交叉研究，患者被随机分配至三个为期4周的阶段，分别接受每日一次20毫克依那普利或每日两次10毫克依那普利的治疗。
北爱尔兰大贝尔法斯特和利斯本地区的普通诊所。
25名高血压患者，在接受4周安慰剂治疗后，平均舒张压在90至110毫米汞柱之间。
血压降低情况及患者依从性评估。
每日一次给药方案的患者依从性更佳。然而，每日两次给药方案与更大程度的血压降低相关，在5%的水平上几乎达到统计学显著性。
依那普利20毫克应开为每日两次，每次10毫克，并采取措施提高患者依从性。
