Rainer G, Menapace R, Schmetterer K, Findl O, Georgopoulos M, Vass C
Department of Ophthalmology, University of Vienna, Austria.
J Cataract Refract Surg. 1999 Dec;25(12):1624-9. doi: 10.1016/s0886-3350(99)00260-6.
To evaluate the effect of dorzolamide 2% and latanoprost 0.005% on intraocular pressure (IOP) after small incision cataract surgery.
Department of Ophthalmology, University of Vienna, Vienna, Austria.
This prospective study comprised 102 eyes of 102 consecutive patients scheduled for small incision cataract surgery. The patients were assigned preoperatively to 1 of 3 groups of 34 each: dorzolamide, latanoprost, and control (no treatment). One drop of the assigned medication was instilled immediately after surgery. Intraocular pressure was measured preoperatively and 6 and 20 to 24 hours postoperatively.
Six hours after surgery, the mean increase in IOP was 1.9 mm Hg +/- 3.9 (SD) in the dorzolamide group (P = .004 versus control), 2.2 +/- 3.0 mm Hg in the latanoprost group (P = .005 versus control), and 4.8 +/- 5.2 mm Hg in the control group. Twenty to 24 hours postoperatively, IOP decreased a mean of -0.9 +/- 3.5 mm Hg in the dorzolamide group (P = .012 versus control) and increased a mean of 0.3 +/- 3.6 mm Hg in the latanoprost group (P = 0.24 versus control) and 1.3 +/- 4.2 mm Hg in the control group. One eye in the dorzolamide group, 1 eye in the latanoprost group, and 4 eyes in the control group had an IOP of 30 mm Hg or higher 6 hours postoperatively.
Six hours postoperatively, dorzolamide and latanoprost were effective in reducing the IOP increase after small incision cataract surgery; however, at 20 to 24 hours, only dorzolamide was effective. Neither drug prevented IOP spikes of 30 mm Hg or higher.
评估2%多佐胺和0.005%拉坦前列素对小切口白内障手术后眼压（IOP）的影响。
奥地利维也纳大学眼科。
这项前瞻性研究纳入了102例连续接受小切口白内障手术患者的102只眼。患者术前被随机分为3组，每组34例：多佐胺组、拉坦前列素组和对照组（不治疗）。术后立即滴入一滴指定药物。术前及术后6小时、20至24小时测量眼压。
术后6小时，多佐胺组眼压平均升高1.9 mmHg±3.9（标准差）（与对照组相比，P = 0.004），拉坦前列素组眼压平均升高2.2±3.0 mmHg（与对照组相比，P = 0.005），对照组眼压平均升高4.8±5.2 mmHg。术后20至24小时，多佐胺组眼压平均下降-0.9±3.5 mmHg（与对照组相比，P = 0.012），拉坦前列素组眼压平均升高0.3±3.6 mmHg（与对照组相比，P = 0.24），对照组眼压平均升高1.3±4.2 mmHg。多佐胺组有1只眼、拉坦前列素组有1只眼、对照组有4只眼在术后6小时眼压达到30 mmHg或更高。
术后6小时，多佐胺和拉坦前列素可有效降低小切口白内障手术后眼压的升高；然而，在20至24小时时，只有多佐胺有效。两种药物均不能预防30 mmHg或更高的眼压峰值。
