Berbeć H, Paszkowska A, Siwek B, Gradziel K, Cybulski M
Department of Physiological Chemistry, Lublin School of Medicine, Poland.
Eur J Gynaecol Oncol. 1999;20(5-6):389-92.
The present study was undertaken to establish the diagnostic utility of total sialic acid (SA) determination in the serum of patient with ovarian neoplasia. In a group of 29 patients with histopathologically confirmed ovarian neoplasia, concentrations of total SA was determined. In addition, the two tumor markers: CA125 antigen level and lactic dehydrogenase (LDH) activity were determined. The mean value of serum total SA in patients (1.76 mmol/L) was significantly higher than in the control group of healthy women (1.52 mmol/L). The elevation of serum total SA was associated with the burden of the tumor: higher total SA levels were observed in the cases of more developed malignancies. A significant correlation has been found between serum total SA content and CA125 level in patients with undifferentiated ovarian cancers. It has been concluded that total serum sialic acid level reflects the development of malignancy and should be considered as a supporting tumor marker in ovarian cancer diagnosis.
本研究旨在确定测定卵巢肿瘤患者血清中总唾液酸（SA）的诊断效用。在一组29例经组织病理学确诊的卵巢肿瘤患者中，测定了总SA的浓度。此外，还测定了两种肿瘤标志物：CA125抗原水平和乳酸脱氢酶（LDH）活性。患者血清总SA的平均值（1.76 mmol/L）显著高于健康女性对照组（1.52 mmol/L）。血清总SA升高与肿瘤负荷相关：在恶性程度更高的病例中观察到总SA水平更高。在未分化卵巢癌患者中，血清总SA含量与CA125水平之间存在显著相关性。得出的结论是，血清总唾液酸水平反映了恶性肿瘤的发展，应被视为卵巢癌诊断中的一种辅助肿瘤标志物。
