Vinke J G, KleinJan A, Severijnen L W, Fokkens W J
Department of Otorhinolaryngology, Erasmus University Medical Centre Rotterdam, The Netherlands.
Int J Pediatr Otorhinolaryngol. 1999 Dec 5;51(2):73-81. doi: 10.1016/s0165-5876(99)00244-x.
Environmental tobacco smoke (ETS) is one of the most common indoor pollutants to which many children are exposed. This study was set up to determine possible effects on cellular infiltrates in the nasal mucosa of children exposed to ETS. The research population consisted of a group of ten children exposed to more then 15 cigarettes/day and a control group of ten children without exposure. The groups were matched for age and gender. None of the children had an atopic constitution. Immunohistochemical staining techniques were used to determine the number of Langerhans cells, T cells, B cells, granulocytes, macrophages, mast cells and eosinophils in the nasal mucosa. IgE+ cells and eosinophils were seen in significantly higher cell numbers in the nasal mucosa of children exposed to ETS (Mann-Whitney U-test). IgE+ mast cells were not found to be more numerous in the ETS-exposed group. We can conclude that exposure to ETS causes changes in cellular infiltrates which partly resemble those seen in the nasal mucosa of allergic children. However, no sign of allergic sensitisation can be found in the nasal mucosa. Children with a genetic predisposition to allergic disease will probably suffer most from the 'unstable' nasal mucosa due to ETS.
环境烟草烟雾（ETS）是许多儿童接触到的最常见的室内污染物之一。本研究旨在确定接触ETS对儿童鼻黏膜细胞浸润的可能影响。研究对象包括一组每天接触超过15支香烟的10名儿童和一组未接触香烟的10名儿童作为对照组。两组在年龄和性别上相匹配。所有儿童均无特应性体质。采用免疫组织化学染色技术测定鼻黏膜中朗格汉斯细胞、T细胞、B细胞、粒细胞、巨噬细胞、肥大细胞和嗜酸性粒细胞的数量。在接触ETS的儿童鼻黏膜中，IgE+细胞和嗜酸性粒细胞的数量明显更高（曼-惠特尼U检验）。在接触ETS的组中未发现IgE+肥大细胞数量更多。我们可以得出结论，接触ETS会导致细胞浸润发生变化，部分类似于过敏性儿童鼻黏膜中所见的变化。然而，在鼻黏膜中未发现过敏致敏的迹象。由于ETS，具有过敏性疾病遗传易感性的儿童可能最容易受到鼻黏膜“不稳定”的影响。
