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老年人颈椎骨折:65例患者生存的影响因素

Cervical spine fractures in the elderly: factors influencing survival in 65 cases.

作者信息

Olerud C, Andersson S, Svensson B, Bring J

机构信息

Department of Orthopaedics, Uppsala University Hospital, Sweden.

出版信息

Acta Orthop Scand. 1999 Oct;70(5):509-13. doi: 10.3109/17453679909000990.

Abstract

To evaluate whether a cervical spine fracture increases the death risk in elderly patients, and to define risk factors, we studied the survival of 65 patients (26 women) with a mean age of 77 (66-99) years. 8 of the patients were tetraparetic. In 35 patients, the upper cervical spine was fractured. 7 patients suffered from ankylosing spondylitis. Severe co-morbidity was present in 16. Survival status and the date of death were retrieved from the government official personal registry. The expected survival was calculated from data retrieved from the Swedish National Board of Health and Welfare. Variables having a possible relation with survival (i.e., a p-value < 0.10 when entered into a Kaplan-Meier survival analysis) were used in a Cox multiple regression survival analysis. 53 (24-105) months after injury, 25 of the 65 patients had died. The survival was significantly lower than the expected values. Severe co-morbidity (risk ratio: 5,6), neurological injury (6,4), high age (1,1), and ankylosing spondylitis (5,5) proved to be significant risk factors for death. Thus, a cervical spine fracture may lead to earlier death in a patient with a severe co-morbidity. A neurological complication constitutes a risk also for a previously healthy individual. Patients having ankylosing spondylitis (with increased death risk) run a higher than normal risk of sustaining a cervical spine fracture.

摘要

为评估颈椎骨折是否会增加老年患者的死亡风险并确定危险因素,我们研究了65例平均年龄为77岁(66 - 99岁)的患者(26名女性)的生存情况。其中8例患者存在四肢轻瘫。35例患者上颈椎骨折。7例患者患有强直性脊柱炎。16例存在严重合并症。生存状态和死亡日期从政府官方个人登记处获取。预期生存情况根据从瑞典国家卫生和福利委员会获取的数据计算得出。在Cox多元回归生存分析中使用了与生存可能相关的变量(即纳入Kaplan - Meier生存分析时p值<0.10的变量)。受伤后53(24 - 105)个月,65例患者中有25例死亡。实际生存率显著低于预期值。严重合并症(风险比:5.6)、神经损伤(6.4)、高龄(1.1)和强直性脊柱炎(5.5)被证明是死亡的显著危险因素。因此,颈椎骨折可能导致患有严重合并症的患者过早死亡。神经并发症对既往健康的个体也构成风险。患有强直性脊柱炎(死亡风险增加)的患者发生颈椎骨折的风险高于正常水平。

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