Brenner S, Matz H
Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Int J Dermatol. 1999 Dec;38(12):928-30. doi: 10.1046/j.1365-4362.1999.00804.x.
Twenty-eight men with AGA, aged 53-76 years (mean, 65 years), were selected to participate in this trial from a double blind, placebo controlled, multicenter study of subjects with moderate symptoms of BPH. Patients received either finasteride 5 mg or placebo daily for 24 months. Hair counts were performed at entry to the study and at 6, 12, 18, and 24 months. Hair counts were made directly on the scalp in a circular target area 1 in in diameter, located in the center of a template. The template was applied in such a way that its counting window fell on the most balding scalp area, which remained the same for each patient.11 At each hair counting session, patients were asked about side-effects and questioned about their sex life. Time trend and differences between groups were examined using a one-way (treatment) MANOVA with repeated measures (baseline, 6, 12, 18, and 24 months). Additional two-tailed t-tests were performed to compare the two groups at each point of time. P < 0.05 was considered to be significant.
28名年龄在53至76岁（平均65岁）之间的雄激素性脱发（AGA）男性，从一项针对中度良性前列腺增生（BPH）症状受试者的双盲、安慰剂对照、多中心研究中被选出来参与本试验。患者每日接受5毫克非那雄胺或安慰剂治疗，为期24个月。在研究开始时以及第6、12、18和24个月时进行毛发计数。毛发计数是在位于模板中心、直径1英寸的圆形目标区域内直接在头皮上进行的。模板的应用方式是使其计数窗口落在每个患者最秃的头皮区域，且该区域保持不变。在每次毛发计数时，询问患者副作用情况并询问其性生活情况。使用带有重复测量（基线、第6、12、18和24个月）的单因素（治疗）多变量方差分析（MANOVA）来检查时间趋势和组间差异。在每个时间点进行额外的双尾t检验以比较两组。P < 0.05被认为具有统计学意义。
