Fernandes G, Yunis E J, Good R A
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1279-83. doi: 10.1073/pnas.73.4.1279.
The longevity of mice of the (NZB X NZW)F1 (B/W) strain and the DBA/2f strain of mice is dramatically prolonged by dietary restriction. B/W mice are susceptible to, and die at an early age from, immunocomplex nephritis. Mice of the DBA/2f strain are also relatively short-lived. Restriction of caloric intake prolonged life of B/W mice more than did protein restriction. DBA/2f mice showed prolongation of life when the diet was restricted only with respect to protein. Caloric restriction alone prolonged life less in DBA/2f mice than in B/W mice. These observations show that dietary manipulations have profound effects on immunity functions, including inhibition of the development of life-shortening autoimmune disease.
饮食限制可显著延长（NZB×NZW）F1（B/W）品系小鼠和DBA/2f品系小鼠的寿命。B/W小鼠易患免疫复合物性肾炎，并早年死于该病。DBA/2f品系小鼠寿命也相对较短。热量摄入限制比蛋白质限制更能延长B/W小鼠的寿命。当仅对蛋白质进行饮食限制时，DBA/2f小鼠的寿命延长。单独的热量限制对DBA/2f小鼠寿命的延长作用小于对B/W小鼠的作用。这些观察结果表明，饮食调控对免疫功能有深远影响，包括抑制缩短寿命的自身免疫性疾病的发展。
