Gajjar A, Kubo C, Johnson B C, Good R A
J Nutr. 1987 Jun;117(6):1136-40. doi: 10.1093/jn/117.6.1136.
Energy restriction increases longevity and life span of B/W mice as it does in mice of other long-lived or short-lived strains. Mice of autoimmune-prone strains that develop certain diseases of aging experience an increase in median longevity when energy intake is restricted early in life. The present experiments analyze the influence of restricting energy intake while feeding constant, adequate and greatly excessive amounts of protein, and constant amounts of minerals and vitamins. The experiments assess the influence of excess protein intake in mice fed ad libitum versus those restricted in energy intake. Ad libitum feeding of diets with protein composition ranging from 15 to 50% did not alter longevity or onset and manifestations of renal disease in B/W mice. In mice consuming a restricted energy intake of a diet providing identical amounts of protein to those consumed by ad libitum-fed mice, whether the protein intake was very high or normal, longevity was equally greatly prolonged. Ad libitum feeding of diets of greatly differing protein content is well tolerated by B/W mice. Both the 15 and 50% protein diets, when ad libitum fed, permitted expression of autoimmune disease and glomerulonephritis in B/W mice but did not adversely influence development or progression of disease. Restriction of energy intake of either the normal protein diet or the high protein diet greatly prolonged the life of mice of the autoimmune-prone, glomerulonephritis-prone B/W strain.
能量限制可延长黑白花小鼠的寿命，就像它对其他长寿或短寿品系的小鼠一样。在生命早期限制能量摄入时，易患自身免疫性疾病且会出现某些衰老疾病的品系小鼠，其平均寿命会增加。本实验分析了在喂食常量、适量和大量过量蛋白质以及常量矿物质和维生素时限制能量摄入的影响。实验评估了自由采食小鼠与能量摄入受限小鼠中过量蛋白质摄入的影响。自由采食蛋白质含量在15%至50%之间的日粮，不会改变黑白花小鼠的寿命、肾病的发病及表现。在摄入能量受限但蛋白质含量与自由采食小鼠相同（无论蛋白质摄入量是非常高还是正常）的日粮的小鼠中，寿命同样大幅延长。黑白花小鼠对自由采食蛋白质含量差异很大的日粮耐受性良好。当自由采食时，15%和50%蛋白质的日粮都能使黑白花小鼠出现自身免疫性疾病和肾小球肾炎，但不会对疾病的发展或进展产生不利影响。限制正常蛋白质日粮或高蛋白日粮的能量摄入，可大大延长易患自身免疫性疾病、易患肾小球肾炎的黑白花品系小鼠的寿命。
