人疱疹病毒6型和人疱疹病毒8型的合并感染在原发性渗出性淋巴瘤中很少见。

Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.

作者信息

Asou H, Tasaka T, Said J W, Daibata M, Kamada N, Koeffler H P

机构信息

Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA.

出版信息

Leuk Res. 2000 Jan;24(1):59-61. doi: 10.1016/s0145-2126(99)00144-7.

DOI:10.1016/s0145-2126(99)00144-7

PMID:10634647

Abstract

The presence and distribution of Epstein-Barr virus (EBV), as well as human herpesvirus-6 and-8 (HHV-6 and HHV-8) was investigated by polymerase chain reaction in 191 samples from a variety of lymphoproliferative disorders. HHV-6 DNA was detected in 18% (30 of 169) of non-HHV-8 related lymphoproliferative disorders, with the highest frequency in AIDS-related lymphomas (8 of 25, 32%). In contrast, HHV-6 DNA was present in less than 5% (1 of 22) of HHV-8 related lymphoproliferative disorders [21 primary effusion lymphomas (PEL), and 1 cases of Castleman disease]. As compared to HHV-6, EBV DNA was frequently detected in PEL (11 of 19 samples, 58%). This study suggests that transformation to PEL is not enhanced by HHV-6, furthermore HHV-6 and -8 may interfere with each other.

摘要

通过聚合酶链反应对191份来自各种淋巴增殖性疾病的样本进行研究，以检测爱泼斯坦-巴尔病毒（EBV）以及人类疱疹病毒6型和8型（HHV-6和HHV-8）的存在和分布情况。在169例与HHV-8无关的淋巴增殖性疾病中，18%（169例中的30例）检测到HHV-6 DNA，在艾滋病相关淋巴瘤中频率最高（25例中的8例，32%）。相比之下，在22例与HHV-8相关的淋巴增殖性疾病[21例原发性渗出性淋巴瘤（PEL）和1例卡斯特曼病]中，HHV-6 DNA的存在率不到5%（22例中的1例）。与HHV-6相比，在PEL中经常检测到EBV DNA（19份样本中的11份，58%）。该研究表明，HHV-6不会增强向PEL的转化，此外，HHV-6和HHV-8可能会相互干扰。