新生儿呼吸窘迫综合征中患者触发通气与传统快速率通气的随机对照试验
Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome.
作者信息
Beresford M W, Shaw N J, Manning D
机构信息
Neonatal Unit, Liverpool Women's Hospital, Crown Street, Liverpool L8 7SS.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 Jan;82(1):F14-8. doi: 10.1136/fn.82.1.f14.
Abstract
AIM
To compare patient triggered, with conventional fast rate, ventilation in a randomised controlled trial using the incidence of chronic lung disease as the primary outcome measure.
METHODS
Three hundred and eighty six preterm infants with birthweights from 1000 to 2000 g, and requiring ventilation for respiratory distress syndrome within 24 hours of birth, were randomised to receive either conventional or trigger ventilation with the SLE 2000 ventilator.
RESULTS
There were no significant differences in the incidence of chronic lung disease (28 day and 36 week definitions), death, pneumothorax, intraventricular haemorrhage, number of ventilator days, or length of oxygen dependency between groups.
CONCLUSIONS
Patient triggered ventilation in preterm infants with respiratory distress syndrome is feasible. No significant differences, when compared with conventional fast rate ventilation in important medium and longer term outcome measures, were evident.
摘要
目的
在一项以慢性肺病发病率作为主要结局指标的随机对照试验中，比较患者触发通气与传统快速通气。
方法
386名出生体重为1000至2000克、出生后24小时内需因呼吸窘迫综合征接受通气的早产儿，被随机分配使用SLE 2000呼吸机接受传统通气或触发通气。
结果
两组在慢性肺病发病率（28天和36周定义）、死亡、气胸、脑室内出血、通气天数或吸氧依赖时长方面无显著差异。
结论
呼吸窘迫综合征早产儿采用患者触发通气是可行的。与传统快速通气相比，在重要的中期和长期结局指标方面无明显差异。
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