Garrido L, Zubía E, Ortega M J, Salvá J
Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Spain.
Steroids. 2000 Feb;65(2):85-8. doi: 10.1016/s0039-128x(99)00083-5.
The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 microg/ml).
柳珊瑚Leptogorgia sarmentosa含有三种新的甾体化合物，（20S）-20-羟基胆甾烷-3,16-二酮（1）、（16S，20S）-16,20-二羟基胆甾烷-3-酮（2）和（20S）-20-羟基胆甾-1-烯-3,16-二酮（3），以及一种已知的相关化合物（4）。它们的结构通过光谱分析确定。这些新的甾体化合物对四种肿瘤细胞系表现出显著的细胞毒性（半数有效剂量ED50 = 1微克/毫升）。
