新型隐球菌D血清型和A血清型菌株中钙调神经磷酸酶在生理功能和毒力方面的作用比较。
Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
作者信息
Cruz M C, Sia R A, Olson M, Cox G M, Heitman J
机构信息
Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Infect Immun. 2000 Feb;68(2):982-5. doi: 10.1128/IAI.68.2.982-985.2000.
Abstract
The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
摘要
在新型隐球菌的D血清型菌株中，钙调神经磷酸酶基因被克隆并破坏。A血清型和D血清型的钙调神经磷酸酶突变体在37℃下无法存活，且对小鼠无致病性，而只有A血清型突变体对阳离子胁迫敏感。因此，钙调神经磷酸酶在A血清型和D血清型菌株中发挥着保守和不同的作用。
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1
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Antimicrob Agents Chemother. 2000 Jan;44(1):143-9. doi: 10.1128/AAC.44.1.143-149.2000.
2
Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption.新型隐球菌ADE2基因的分子分析，一种用于转化和基因破坏的选择标记。
Fungal Genet Biol. 1999 Jun;27(1):36-48. doi: 10.1006/fgbi.1999.1126.
3
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5
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8
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10
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Genes Dev. 1997 Dec 15;11(24):3432-44. doi: 10.1101/gad.11.24.3432.
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