West R, Courts S, Beharry S, May S, Hajek P
St. George's Hospital Medical School, London, UK.
Psychopharmacology (Berl). 1999 Dec;147(3):319-21. doi: 10.1007/s002130051174.
Previous research suggests that glucose may reduce desire to smoke during periods of abstinence but a definitive test is needed.
The present study aimed to determine whether a single administration of oral glucose would reduce desire to smoke in abstaining smokers.
Thirty-eight smokers attended the laboratory in the afternoon having not smoked since the previous evening. They rated their desire to smoke immediately before and at 5-min intervals for 20 min after chewing four 3-g glucose tablets (experimental group) or four matched placebo tablets (control group).
Ratings of desire to smoke decreased to a greater extent in the experimental than the control group. The effect was apparent after 10 min. There was no difference between the groups in terms of feeling "sick" or "satisfied".
A single dose of glucose has a relatively rapid and detectable effect on desire to smoke and the effect is not mediated by feeling sick. Glucose tablets may be useful in helping to control desire to smoke during periods of abstinence.
先前的研究表明，葡萄糖可能会在戒烟期间降低吸烟欲望，但仍需要进行确定性测试。
本研究旨在确定单次口服葡萄糖是否会降低戒烟者的吸烟欲望。
38名吸烟者于下午前往实验室，自前一晚起未吸烟。他们在咀嚼四片3克葡萄糖片（实验组）或四片匹配的安慰剂片（对照组）之前及之后每隔5分钟对吸烟欲望进行评分，共持续20分钟。
与对照组相比，实验组的吸烟欲望评分下降幅度更大。10分钟后效果明显。两组在感觉“恶心”或“满足”方面没有差异。
单剂量葡萄糖对吸烟欲望有相对快速且可检测到的影响，且这种影响不是由恶心感介导的。葡萄糖片可能有助于控制戒烟期间的吸烟欲望。
