Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, UK Centre for Tobacco and Alcohol Studies, University of Oxford, Woodstock Road, Oxford OX2 6GG, UK.
BMC Public Health. 2013 Dec 13;13:1176. doi: 10.1186/1471-2458-13-1176.
Smokers attend preferentially to cigarettes and other smoking-related cues in the environment, in what is known as an attentional bias. There is evidence that attentional bias may contribute to craving and failure to stop smoking. Attentional retraining procedures have been used in laboratory studies to train smokers to reduce attentional bias, although these procedures have not been applied in smoking cessation programmes. This trial will examine the efficacy of multiple sessions of attentional retraining on attentional bias, craving, and abstinence in smokers attempting cessation.
METHODS/DESIGN: This is a double-blind randomised controlled trial. Adult smokers attending a 7-session weekly stop smoking clinic will be randomised to either a modified visual probe task with attentional retraining or placebo training. Training will start 1 week prior to quit day and be given weekly for 5 sessions. Both groups will receive 21 mg transdermal nicotine patches for 8-12 weeks and withdrawal-orientated behavioural support for 7 sessions. Primary outcome measures are the change in attentional bias reaction time and urge to smoke on the Mood and Physical Symptoms Scale at 4 weeks post-quit. Secondary outcome measures include differences in withdrawal, time to first lapse and prolonged abstinence at 4 weeks post-quit, which will be biochemically validated at each clinic visit. Follow-up will take place at 8 weeks, 3 months and 6 months post-quit.
This is the first randomised controlled trial of attentional retraining in smokers attempting cessation. This trial could provide proof of principle for a treatment aimed at a fundamental cause of addiction.
Current Controlled Trials: ISRCTN54375405.
吸烟者在环境中更倾向于注意香烟和其他与吸烟相关的线索，这被称为注意力偏向。有证据表明，注意力偏向可能导致渴望和戒烟失败。在实验室研究中，已经使用注意再训练程序来训练吸烟者减少注意力偏向，尽管这些程序尚未应用于戒烟计划中。这项试验将研究多次注意力再训练对戒烟者注意力偏向、渴望和戒断的疗效。
方法/设计：这是一项双盲随机对照试验。参加为期 7 周的每周戒烟诊所的成年吸烟者将被随机分配到改良的视觉探测任务注意力再训练或安慰剂训练中。训练将在戒烟前一周开始，每周进行 5 次。两组都将接受 21 毫克经皮尼古丁贴片治疗 8-12 周，并接受为期 7 次的戒断定向行为支持。主要结局指标是戒烟后 4 周时心境和身体症状量表上注意力偏向反应时间和吸烟欲望的变化。次要结局指标包括戒烟后 4 周时的戒断、首次复吸时间和长期戒断的差异，这将在每次就诊时进行生物化学验证。随访将在戒烟后 8 周、3 个月和 6 个月进行。
这是首次在试图戒烟的吸烟者中进行的注意力再训练随机对照试验。该试验可能为针对成瘾根本原因的治疗提供原理证明。
当前对照试验：ISRCTN54375405。
