Rivera R, Chen-Mok M, McMullen S
International Medical Affairs, Family Health International, Research Triangle Park, NC 27709, USA.
Contraception. 1999 Sep;60(3):155-60. doi: 10.1016/s0010-7824(99)00077-3.
The purpose of this study was to analyze the reasons for early discontinuation of the TCu-380A IUD in women participating in a large multicenter trial. The study relates specific characteristics of the women at the time of TCu-380A insertion with specific 1-year reasons for discontinuation. A secondary analysis was performed on data obtained from 2748 women from sites in Africa, Asia, and Latin America. By the end of the year, 321 discontinuations were observed. The gross cumulative 12-month life table rates of reasons for discontinuation were 13.3 for all reasons and 3.1, 4.5, and 4.3 for expulsion, removals for bleeding/pain, and personal reasons, respectively. Study site, age, and religion had a significant effect on early discontinuation. Women who had IUD insertions in the African centers had significantly higher expulsion rates than women from other centers. Women < 20 years old had significantly higher expulsion rates than older women. Muslim women had significantly higher rates of removal for bleeding and pain than women of other religions. This information may guide the counseling and follow-up process of women with such characteristics and result in a more satisfactory use and improved continuation rates of the TCu 380A.
本研究的目的是分析参与一项大型多中心试验的女性中早期停用TCu - 380A宫内节育器（IUD）的原因。该研究将TCu - 380A置入时女性的特定特征与特定的1年停用原因联系起来。对从非洲、亚洲和拉丁美洲各研究点的2748名女性获得的数据进行了二次分析。到年底时，观察到321例停用情况。所有原因导致的停用的12个月累计生命表总发生率为13.3，因排出、因出血/疼痛取出以及个人原因导致的停用发生率分别为3.1、4.5和4.3。研究点、年龄和宗教对早期停用有显著影响。在非洲研究中心置入IUD的女性的排出率显著高于其他中心的女性。年龄小于20岁的女性的排出率显著高于年龄较大的女性。穆斯林女性因出血和疼痛取出IUD的发生率显著高于其他宗教的女性。这些信息可能会指导具有此类特征的女性的咨询和随访过程，并使TCu 380A的使用更令人满意且提高其续用率。
