Farr G, Rivera R
Family Health International, Research Triangle Park, NC 27709.
Am J Obstet Gynecol. 1992 Jul;167(1):144-51. doi: 10.1016/s0002-9378(11)91649-4.
This paper is a reassessment of earlier findings from a preliminary analysis of data from a multicenter international trial regimen on breast-feeding and non-breast-feeding women in which events related to insertion, expulsion, and removal of the TCu-380A intrauterine contraceptive device (ParaGard 380) were investigated.
Performance of the TCu-380A through 12 months after insertion was compared with life-table rate analysis, chi 2, Fisher exact test, or Student's t test. Variables were events reported during intrauterine contraceptive device insertion and events throughout the 12 months of study participation by breast-feeding status.
Breast-feeding among intrauterine contraceptive device users was associated with fewer insertion-related complaints and lower removal rates for bleeding and pain. No uterine perforations were reported throughout the study.
Differences in the performance of the TCu-380A intrauterine contraceptive device suggest physiologic effects associated with lactational amenorrhea. The TCu-380A intrauterine contraceptive device is a viable option for women breast-feeding at the time of intrauterine contraceptive device insertion.
本文是对一项关于母乳喂养和非母乳喂养女性的多中心国际试验方案数据初步分析的早期研究结果的重新评估，该研究调查了与TCu-380A宫内节育器（帕拉戈德380）的插入、排出和取出相关的事件。
通过生命表率分析、卡方检验、费舍尔精确检验或学生t检验，比较了TCu-380A在插入后12个月内的性能。变量包括宫内节育器插入期间报告的事件以及根据母乳喂养状况在整个12个月研究参与期间的事件。
宫内节育器使用者中的母乳喂养与较少的插入相关投诉以及较低的因出血和疼痛而取出的比率相关。在整个研究过程中未报告子宫穿孔情况。
TCu-380A宫内节育器性能的差异表明与哺乳期闭经相关的生理效应。对于在宫内节育器插入时正在母乳喂养的女性，TCu-380A宫内节育器是一种可行的选择。
