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Lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH): a scoping review unveils clinical and diagnostic patterns of a lymphoma subgroup with poor prognosis.淋巴瘤相关噬血细胞性淋巴组织细胞增生症（LA-HLH）：一项范围综述揭示了预后不良的淋巴瘤亚组的临床和诊断模式。
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AN UNUSUAL CAUSE OF ACUTE ABDOMEN: SPLENIC INFARCTION.急性腹痛的一种罕见病因：脾梗死。
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Flow cytometry as a diagnostic tool in the early diagnosis of aggressive lymphomas mimicking life-threatening infection.流式细胞术作为一种诊断工具，用于早期诊断酷似危及生命感染的侵袭性淋巴瘤。
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Primary hepatosplenic large B-cell lymphoma: a rare aggressive tumor.原发性肝脾大B细胞淋巴瘤：一种罕见的侵袭性肿瘤。
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肝脾B细胞淋巴瘤合并噬血细胞综合征：一例报告

Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report.

作者信息

Kwon S Y, Lee J J, Chung I J, Kim H J, Park M R, Kim H S, Park C S

机构信息

Department of Internal Medicine, National University Medical School, Kwangju, Korea.

出版信息

J Korean Med Sci. 1999 Dec;14(6):671-4. doi: 10.3346/jkms.1999.14.6.671.

DOI:10.3346/jkms.1999.14.6.671
PMID:10642947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3054438/
Abstract

While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.

摘要

虽然与噬血细胞综合征（HPS）相关的T细胞非霍奇金淋巴瘤（NHL）已屡见不鲜，但与HPS相关的B细胞NHL却鲜有报道。我们报告一例41岁女性肝脾B细胞淋巴瘤合并HPS的病例，该患者以不明原因发热就诊。腹部CT扫描显示脾肿大伴局灶性脾梗死。脾切除术及肝楔形活检显示中到大肿瘤细胞呈窦状浸润，对B淋巴细胞标志物呈阳性反应。骨髓检查结果显示组织细胞增生并伴有活跃的噬血细胞现象。