Yoshikawa M, Yamane Y, Yoneda S, Iwasawa S, Nishimura K, Kawamoto H, Nakano H, Fukui H, Nakamine H
Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
J Gastroenterol. 1998 Dec;33(6):880-5. doi: 10.1007/s005350050193.
We report a 75-year-old Japanese man infected with hepatitis C virus (HCV) who died of acute hepatic failure due to the hepatic infiltration of B-cell non-Hodgkin's lymphoma (NHL) cells. He suddenly developed jaundice, fatigue, fever, and hepatosplenomegaly during the course of chronic infection with HCV. Postmortem liver necropsy revealed extensive infiltration of lymphoma cells into the liver. Although the association between HCV infection and NHL has recently become a matter of concern, we believe this to be the first reported case of acute hepatic failure caused by hepatic involvement of non-Hodgkin's lymphoma in an HCV-infected patient.
我们报告一例75岁感染丙型肝炎病毒（HCV）的日本男性，其死于B细胞非霍奇金淋巴瘤（NHL）细胞肝浸润所致的急性肝衰竭。在慢性HCV感染过程中，他突然出现黄疸、乏力、发热及肝脾肿大。尸检肝脏病理显示淋巴瘤细胞广泛浸润肝脏。尽管HCV感染与NHL之间的关联近来已受到关注，但我们认为这是首例报道的HCV感染患者因非霍奇金淋巴瘤肝脏受累导致急性肝衰竭的病例。
