从四角风车子中分离得到的13种新型环阿尔廷型三萜类化合物。

Thirteen novel cycloartane-type triterpenes from Combretum quadrangulare.

作者信息

Banskota A H, Tezuka Y, Tran K Q, Tanaka K, Saiki I, Kadota S

机构信息

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan.

出版信息

J Nat Prod. 2000 Jan;63(1):57-64. doi: 10.1021/np990336q.

DOI:10.1021/np990336q

PMID:10650080

Abstract

Thirteen novel cycloartane-type triterpenes were isolated from Combretum quadrangulare, a Vietnamese medicinal plant. The structures of the novel triterpenes were determined by spectroscopic methods as well as by chemical transformations. Among those compounds, quadrangularic acids F (1), G (2), and H (4) and 24-epiquadrangularic acid G (3) are the first examples of cycloartane-type triterpenes bearing carboxylic acid groups at both C-4 and C-20. Furthermore, norquadrangularic acid A (13) is the first example of a trinorcycloartane-type triterpene isolated from the genus Combretum.

摘要

从越南药用植物四角风车子（Combretum quadrangulare）中分离出了13种新型环阿尔廷型三萜。通过光谱方法以及化学转化确定了这些新型三萜的结构。在这些化合物中，四角酸F（1）、G（2）和H（4）以及24-表四角酸G（3）是在C-4和C-20位均带有羧酸基团的环阿尔廷型三萜的首个实例。此外，去甲四角酸A（13）是从风车子属植物中分离出的首个降三降环阿尔廷型三萜的实例。