Mimaki Yoshihiro, Kuroda Minpei, Yokosuka Akihito, Harada Hiroshi, Fukushima Masato, Sashida Yutaka
Laboratory of Medicinal Plant Science, Tokyo University of Pharmacy and Life Science, School of Pharmacy, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 2003 Aug;51(8):960-5. doi: 10.1248/cpb.51.960.
To characterize the stems of Akebia trifoliata chemically, a detailed phytochemical examination was carried out on A. trifoliata stems, with particular attention to the triterpene and triterpene saponin constituents, and resulted in the isolation of three new triterpenes (1-3) and three new triterpene saponins (11-13), together with seven known triterpenes (4-10) and 12 known triterpene saponins (14-25). The structures of the new compounds were determined on the basis of spectroscopic analysis, including two-dimensional NMR spectroscopic data, and the results of hydrolysis. Four saponins (22-25), which were obtained in good yields and were not isolated from Akebia quinata stems, are concluded to be applicable as marker compounds in chemically distinguishing between A. trifoliata and A. quinata by conventional TLC examination. To the best our knowledge, the current work is the first chemical investigation of A. trifoliata.
为了对三叶木通茎进行化学特征分析，对三叶木通茎进行了详细的植物化学研究，特别关注三萜和三萜皂苷成分，结果分离出三种新的三萜（1 - 3）和三种新的三萜皂苷（11 - 13），以及七种已知的三萜（4 - 10）和十二种已知的三萜皂苷（14 - 25）。新化合物的结构基于光谱分析确定，包括二维核磁共振光谱数据以及水解结果。四种皂苷（22 - 25）产量良好且未从五叶木通茎中分离得到，经推断可作为通过传统薄层色谱检查在化学上区分三叶木通和五叶木通的标记化合物。据我们所知本研究是对三叶木通的首次化学研究。
